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March 15, 2026Blood Vessels Thrombosis & HemostasisOpen Access

The Impact of Hereditary TTP on Psychological Health, Cognition, and Well-Being: A Patient-Reported Outcomes Study

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Authors

ABAzra BorogovacJAJoanne AlbertJNJulia Naifeh

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Overview

Patient-reported outcomes reveal worse fatigue and anxiety in hereditary TTP, suggesting chronic psychological effects.

Key Points

  • This study evaluates the impact of hereditary TTP on psychological health and cognitive function compared to the general population.
  • Patients with hereditary TTP completed PROMIS assessments regarding psychological health and cognitive function.
  • Comparative analysis conducted against the US population and chronic disorders using t-tests and repeated measures analysis.
  • Longitudinal assessments tracked changes in symptoms over 6 months and 1 year.
  • Patients reported significantly worse fatigue, depression, anxiety, and cognitive function compared to the US population.
  • Scores were similar to or worse than those from patients with other chronic disorders.
  • No significant changes in scores were observed over time, highlighting persistent impairments.

Cite This Study

Borogovac et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff4f83145bc643d1b994https://doi.org/10.1016/j.bvth.2026.100159
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The impact of hereditary TTP on psychological health, cognition, and well-being: a patient-reported outcomes study.2026
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