What does this research mean for the field?

Survivors of acute autoimmune thrombotic thrombocytopenic purpura have a significantly higher prevalence of depressive symptoms compared to healthy controls, with depression severity negatively correlated with resilience. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 19, 2021Journal of Clinical MedicineOpen Access

Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Autoimmune Thrombotic Thrombocytopenic Purpura (iTTP) (n=238). Intervention: History of acute autoimmune thrombotic thrombocytopenic purpura (iTTP) vs. Healthy controls. Primary outcome: Prevalence of depressive symptoms (PHQ-9 score ≥ 5) (p=<0.001).

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Key result

Acute autoimmune TTP survival is linked to an ~82% higher prevalence of depressive symptoms versus controls.

P<0.001
n=238

Why the study?

Survivors of autoimmune thrombotic thrombocytopenic purpura have a high prevalence of depression and impaired cognitive function, but the influence of life circumstances and personality on depression, anxiety, and quality of life is unclear.

Population

104 iTTP patients and controls

Comparison

104 iTTP patients vs controls

Design

Case-control study using validated questionnaires

Authors

TFTanja Falter SBSibylle Böschen MSMarkus Schepers

Discussion

Member takes

Overview

May warrant mental health screening in TTP survivors; hypothesis-generating for resilience-targeted interventions.

Study Design

Type

Cohort (n=238)

Multicenter

Structured PICO

Population

238 participants, comprising 104 adult survivors of acute autoimmune thrombotic thrombocytopenic purpura and 134 age- and sex-matched healthy controls, evaluated for long-term psychological consequences.

Comparator

Controls

Outcome

Prevalence of depression and anxiety symptoms, subjective cognitive deficits, quality of life, attitude to life and resilience measured via validated questionnairespatient reported

Main Result

Absolute Event Rate: 61.4% vs 33.8%

p-value: p=<0.001

Survivors of autoimmune thrombotic thrombocytopenic purpura have a high prevalence of depression, anxiety, and cognitive impairment, which are negatively correlated with resilience.

Limitations

Use of self-report questionnaires without clinical examination
Response rate of only about 60% among iTTP survivors, introducing potential selection bias
Comorbidities were not confirmed beyond self-reporting
Lack of baseline data on mental illness or resilience prior to the iTTP diagnosis

Cite This Study

Falter et al. (2021) conducted a cohort in Autoimmune Thrombotic Thrombocytopenic Purpura (iTTP) (n=238). History of acute autoimmune thrombotic thrombocytopenic purpura (iTTP) vs. Healthy controls was evaluated on Prevalence of depressive symptoms (PHQ-9 score ≥ 5) (p=<0.001). Survivors of acute autoimmune thrombotic thrombocytopenic purpura had a significantly higher prevalence of depressive symptoms compared to healthy controls (61.4% vs 33.8%, p<0.001).

synapsesocial.com/papers/6aa503df6803e1e7a1f2e508 https://doi.org/10.3390/jcm10020365

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January 19, 2021Journal of Clinical MedicineOpen Access

Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura

View Full Paper

Ask AI

Bookmark

Key result

Acute autoimmune TTP survival is linked to an ~82% higher prevalence of depressive symptoms versus controls.

P<0.001
n=238

Why the study?

Population

104 iTTP patients and controls

Comparison

104 iTTP patients vs controls

Design

Case-control study using validated questionnaires

Authors

TFTanja Falter SBSibylle Böschen MSMarkus Schepers

Discussion

Member takes

Overview

May warrant mental health screening in TTP survivors; hypothesis-generating for resilience-targeted interventions.

Study Design

Type

Cohort (n=238)

Multicenter

Structured PICO

Population

Comparator

Controls

Outcome

Prevalence of depression and anxiety symptoms, subjective cognitive deficits, quality of life, attitude to life and resilience measured via validated questionnairespatient reported

Main Result

Absolute Event Rate: 61.4% vs 33.8%

p-value: p=<0.001

Survivors of autoimmune thrombotic thrombocytopenic purpura have a high prevalence of depression, anxiety, and cognitive impairment, which are negatively correlated with resilience.

Limitations

Use of self-report questionnaires without clinical examination
Response rate of only about 60% among iTTP survivors, introducing potential selection bias
Comorbidities were not confirmed beyond self-reporting
Lack of baseline data on mental illness or resilience prior to the iTTP diagnosis

Cite This Study

synapsesocial.com/papers/6aa503df6803e1e7a1f2e508 https://doi.org/10.3390/jcm10020365

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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