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October 1, 2025MedicineOpen Access

Diagnostic value of pyruvate kinase isoenzyme type M2 for colorectal cancer: Evidence from meta-analysis

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Authors

HZHang ZhaoStomatology HospitalXSXiaonan SunShenyang The Fourth Hospital of PeopleYWYing WangShanxi Provincial Children's Hospital

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Overview

Meta-analysis reveals high sensitivity and specificity of pyruvate kinase isoenzyme type M2 for colorectal cancer, suggesting its potential diagnostic role.

Key Points

  • The meta-analysis found a pooled sensitivity of 77% and specificity of 83% for M2-PK in diagnosing colorectal cancer.
  • Based on data from 27 studies, M2-PK also demonstrated a high area under the ROC curve, measuring 87%.
  • Subgroup analyses were performed according to race, test method, sample type, and tumor staging to assess heterogeneity.
  • High-quality prospective studies are needed to further confirm the diagnostic value of M2-PK in colorectal cancer.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68dd91d5fe798ba2fc499159https://doi.org/10.1097/md.0000000000036942
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  1. 1Diagnostic value of tumor m2-pyruvate kinase level in lung cancer and its relationship with tumor histological type2024
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  4. 4The ratio of PKM1/PKM2 is the key factor affecting the glucose metabolism and biological function of colorectal cancer cells2024
  5. 5Feasibility of Using Point-of-Care Isoenzyme Type M2 Pyruvate Kinase Quick Stool Test to Facilitate Earlier Diagnosis of Gastric Cancer in Rwanda2026