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September 16, 2025Asian Pacific Journal of Cancer PreventionOpen Access

Prognostic Value of PKM2 Expression in de novo Metastatic Colorectal Cancer Patients

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Authors

ARAhmed RefaatAssiut UniversityNHNada Mohammad HussienAssiut UniversityRFRabab Mohamed Mumdouh FarghalyAssiut University

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Overview

This prospective cohort study examines PKM2 expression's impact on survival in metastatic colorectal cancer, suggesting its potential as a therapeutic target.

Key Points

  • High PKM2 expression correlates significantly with lower overall response rates to chemotherapy, P = 0.001.
  • After 13 months of follow-up, patients with high PKM2 levels had significantly lower progression-free survival (6 months) compared to lower levels (10 months), P = 0.008.
  • The association between elevated PKM2 and overall survival was also significant, with median survival of 12 months for high expression versus 17 months for low, P = 0.008.
  • PKM2 expression was identified as an independent prognostic factor for overall survival, supporting its potential role in colorectal cancer management.

Cite This Study

Refaat et al. (2025) studied this question.

synapsesocial.com/papers/68d44f8331b076d99fa57118https://doi.org/10.31557/apjcp.2025.26.9.3485
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Also Consider

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  5. 5PKM2 phosphorylation by c-SRC activates glycolysis and metastasis with the stimulation of tumor-associated macrophages2026