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October 1, 2025Medical Journal of BabylonOpen Access

Cellular Response of Thymic Macrophages to Exogenous Specific Pineal Hormone

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Authors

NKNibras Hatim KhameesKNKhalida I. NoelSESamia A. Eleiwe

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Overview

Observational analysis reveals altered immune response in thymic macrophages after melatonin treatment, suggesting dose-dependent effects.

Key Points

  • Treatment with melatonin increased the prevalence of unusual macrophage types, indicating immune modulation.
  • Large macrophages and multinuclear giant cells were significantly more common in melatonin-treated groups compared to controls.
  • Morphometric analysis showed a rise in macrophage diameter and nuclear size with increasing melatonin doses.
  • High doses of melatonin may negatively affect immune responses, highlighting the importance of dosage.

Cite This Study

Khamees et al. (2025) studied this question.

synapsesocial.com/papers/68dd91dafe798ba2fc499516https://doi.org/10.4103/mjbl.mjbl_634_23
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IMMUNE-PINEAL AXIS: A SHUTTLE BETWEEN ENDOCRINE AND PARACRINE MELATONIN PRODUCTION2009
  2. 28698 Unique populations of pituitary macrophages regulate gonadotropin secretion2024
  3. 3MT1/MT2 melatonin receptors in proinflammatory T helper cell populations2025
  4. 4Diminished Pro-Inflammatory Characteristics in Murine Bone Marrow Derived Macrophages with Impaired Thyroid Hormone Receptor Alpha 1 Signaling2026
  5. 5Melatonin reduces inflammatory response in peripheral T helper lymphocytes from relapsing-remitting multiple sclerosis patients2017