Assessment of Galectin-3 with Biochemical Changes in Patients with Chronic Kidney Disease

The existence of renal impairment or an estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 mt 2 , regardless of the etiology, that lasts for three months or more is referred to as chronic kidney disease (CKD). The 30 kDa lectin known as galectin-3, or Gal-3, is linked to several pathophysiological processes, including fibrosis and kidney injury. Gal-3 uses its carbohydrate recognition domain to bind β-galactoside. assessing the relationship between glomerular filtration rate (GFR) and plasma Gal-3 content in hemodialysis patients with CKD. This study included 90 patients in a case–control design, 45 of whom had been diagnosed with chronic renal disease and 45 of whom appeared to be in good condition. To quantify Gal-3, blood samples were obtained. Age and BMI were among the other characteristics that were measured. The diagnostic accuracy of Gal-3 was assessed using statistical methods, such as receiver operating characteristic (ROC)-curve analysis. The present investigation discovered a statistically significant increase in Gal-3 concentration in the control group at P value significant ( P ˂ 0.05). Moreover, the Gal-3 ROC yielded an area under the curve of 77%. The findings highlight the critical function that Gal-3 plays in chronic renal disease.