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October 1, 2025CancersOpen Access

Functional Heterogeneity and Context-Dependent Roles of LncRNAs in Breast Cancer

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Authors

SLShu Hui LyeNPNunaya PolycarpTDTitilayomi Juliet Durojaye

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Overview

This review highlights the roles of long non-coding RNAs in breast cancer, suggesting strategies to overcome their heterogeneity in precision medicine.

Key Points

  • Long non-coding RNAs show diverse roles in breast cancer, either promoting or inhibiting tumor-related processes.
  • Their functional heterogeneity complicates therapeutic applications, highlighting the need for improved classification and targeted research.
  • Strategies like CRISPR/Cas and single-cell sequencing are vital for understanding lncRNA functions and enhancing clinical utility.
  • Contextual factors such as subtype differences and the tumor microenvironment significantly influence lncRNA behavior in breast cancer.

Cite This Study

Lye et al. (2025) studied this question.

synapsesocial.com/papers/68dd9537fe798ba2fc499728https://doi.org/10.3390/cancers17193191
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Harnessing the potential of long non-coding RNAs in breast cancer: from etiology to treatment resistance and clinical applications2024 · 7 citations
  2. 2Non-coding RNAs as novel biomarkers and therapeutic targets in breast cancer2025
  3. 3Comprehensive Transcriptome Analysis Expands lncRNA Functional Profiles in Breast Cancer2024 · 3 citations
  4. 4LncRNAs as regulators of chemoresistance and chemosensitivity in triple-negative breast cancer2026
  5. 5An Evaluation of Long Non-coding RNAs and Cancer2024