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This is a Literature Review study.

October 2, 2025

The Dual Role of Transforming Growth Factor-Beta (TGF-β) Signaling: Balancing Cellular Senescence and Tumor Progression for Precision Therapeutics.

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This review analyzes TGF-β's dual role in cellular senescence and tumor progression, highlighting its significance in therapeutic strategies.

TGF-β signaling regulates cellular senescence and tumor progression, acting as both a tumor suppressor and promoter.
In normal tissues, TGF-β functions to suppress tumors by inducing apoptosis and maintaining ECM integrity.
In the tumor microenvironment, sustained TGF-β signaling promotes tumor growth, immune evasion, and resistance to therapies.
Understanding TGF-β's dual role is crucial for optimizing precision medicine approaches to improve cancer treatment outcomes.

Liao et al. (2025) studied this question.

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This review analyzes TGF-β's dual role in cellular senescence and tumor progression, highlighting its significance in therapeutic strategies.