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October 2, 2025Journal of Anaesthesiology Clinical PharmacologyOpen Access

Comparing the prophylactic effect of ondansetron versus ephedrine on hemodynamic instability caused by spinal anesthesia for cesarean section

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Authors

SKSaeed KhademiShiraz University of Medical SciencesPBParnian BaghbanShiraz University of Medical SciencesFKFatemeh KhaliliIslamic Azad University of Tabriz

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Implication

Randomized trial found lower hypotension incidence with ephedrine versus ondansetron in expectant mothers, suggesting improved outcomes.

Key Points

  • Ephedrine significantly reduced maternal hypotension during spinal anesthesia compared to ondansetron.
  • Hypotension occurred in 21.7% of the ephedrine group, compared to 60% in the ondansetron group.
  • The trial involved 120 parturients receiving either ephedrine or ondansetron to compare effects.
  • No significant differences in complications or satisfaction between the two groups were noted.

Cite This Study

Khademi et al. (2025) studied this question.

synapsesocial.com/papers/68de5da283cbc991d0a2067chttps://doi.org/10.4103/joacp.joacp_382_24
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effects of Intravenous Ephedrine During Spinal Anesthesia for Cesarean Delivery: A Randomized Controlled Trial2009 · 50 citations
  2. 2Effectiveness of prophylactic ondansetron in preventing spinal anesthesia induced hypotension and bradycardia in pregnant mother undergoing elective cesarean delivery: A double blinded randomized control trial, 20212021 · 6 citations
  3. 3The Bainbridge and the “Reverse” Bainbridge Reflexes2011 · 153 citations