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October 2, 2025International Journal of Molecular SciencesOpen Access

Gene Expression Profile of Placenta and Adipose Tissue in Women with Gestational Diabetes Mellitus

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Authors

RSRenata SaucedoEMErika Magallón-GayónRCRocío Alejandra Chávez-Santoscoy

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Overview

Analysis reveals altered gene expression in placenta and adipose tissue of women with gestational diabetes mellitus, indicating critical molecular pathways involved.

Key Points

  • A total of 179 differentially expressed genes were identified in the placenta, indicating substantial changes in gene expression.
  • RNA sequencing revealed significant alterations in gene pathways related to metabolism and signaling in gestational diabetes mellitus.
  • Differential expression analysis showed upregulated genes involved in G-protein-coupled receptor signaling and downregulated genes linked to cell motility.
  • This work highlights the potential involvement of disordered molecular pathways in the pathogenesis of gestational diabetes mellitus.

Cite This Study

Saucedo et al. (2025) studied this question.

synapsesocial.com/papers/68de68e583cbc991d0a20ed7https://doi.org/10.3390/ijms26199595
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Also Consider

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  4. 4Decoding the molecular landscape of the placenta in maternal diabetes: a systematic review of high-throughput data2026 · 2 citations
  5. 51965-LB: Metabolomic and Transcriptomic Signatures of Gestational Diabetes Mellitus (GDM) Suggest Nutritional and Inflammatory Pathways in Intergenerational Transfer of Risk2024