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March 22, 2017Biomedical ReportsOpen Access

Microarray analysis identified 935 differentially expressed genes (450 downregulated and 485 upregulated) in the omental visceral adipose tissue of pregnant women with gestational diabetes mellitus compared to those without.

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Population

Pregnant Chinese women with and without gestational diabetes mellitus (GDM) undergoing caesarian section

Design

Cross-sectional

Key result

Microarray analysis identified 935 differentially expressed genes (450 downregulated and 485 upregulated) in the omental visceral adipose tissue of pregnant women with gestational diabetes mellitus compared to those without.

Authors

QYQian YuanHSHao SunHXHongli Xiao

Discussion

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Overview

May implicate immune-inflammatory pathways in GDM insulin resistance; cross-sectional data leaves causal roles open for prospective validation.

Study Design

Type

Case-Control (n=6)

Multicenter

No

Structured PICO

P
Population
6 pregnant Chinese women (3 with gestational diabetes mellitus and 3 with normal glucose tolerance) undergoing caesarean section, evaluated for differentially expressed genes in omental visceral adipose tissue.
C
Comparator
Pregnant women without GDM
O
Outcome
Differentially expressed genes (DEGs) and their associated functions and pathways in omental visceral adipose tissuesurrogate

Gene expression profiling of omental visceral adipose tissue in GDM identifies immune and inflammatory pathways as key mechanisms associated with insulin resistance.

Limitations

  • Low number of study subjects
  • Differential expression of certain genes may have been a result, but not necessarily a cause of GDM

Cite This Study

Yuan et al. (2017) conducted a case-control in Gestational diabetes mellitus (n=6). Gestational diabetes mellitus vs. Normal glucose tolerance was evaluated on Differentially expressed genes (DEGs) in omental visceral adipose tissue. Microarray analysis identified 935 differentially expressed genes (450 downregulated and 485 upregulated) in the omental visceral adipose tissue of pregnant women with gestational diabetes mellitus compared to those without.

synapsesocial.com/papers/6a62cedd50e2b8a4ef6a6fc2https://doi.org/10.3892/br.2017.878
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gene Expression Profile of Placenta and Adipose Tissue in Women with Gestational Diabetes Mellitus2025
  2. 22D-DIGE to identify proteins associated with gestational diabetes in omental adipose tissue2013 · 54 citations
  3. 3Placental transcriptome profiling and immune signature differences in pregnancies with and without gestational diabetes mellitus: An observational study2026 · 1 citations
  4. 4Comprehensive Genetic and Pathway Analysis of Gestational Diabetes: A Multidimensional Bioinformatics Approach2025
  5. 5The integrated bioinformatic analysis identifies immune microenvironment-related potential biomarkers for patients with gestational diabetes mellitus2024 · 4 citations