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May 24, 2013Journal of EndocrinologyOpen Access

2D-DIGE to identify proteins associated with gestational diabetes in omental adipose tissue

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Population

12 pregnant women undergoing term Caesarean section, comprising 6 with gestational diabetes mellitus and 6…

Design

Case-control

Authors

KOKaren OlivaThe Alfred HospitalGBGillian BarkerKarolinska University HospitalGRGregory E. RiceUniversity of Waterloo

Discussion

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Implication

Supports visceral adiposity in GDM pathogenesis via proteomic shifts; hypothesis-generating and should not yet change practice.

Structured PICO

P
Population
12 pregnant women undergoing term Caesarean section, comprising 6 with gestational diabetes mellitus (GDM) and 6 with normal glucose tolerance (NGT)
C
Comparator
Normal glucose tolerance (NGT)
O
Outcome
Differential protein expression in omental adipose tissuesurrogate

Proteomic analysis of omental fat reveals differential expression of proteins involved in inflammation, lipid/glucose metabolism, and oxidative stress in GDM, supporting the role of visceral adiposity in its pathogenesis.

Cite This Study

Oliva et al. (2013) studied this question.

synapsesocial.com/papers/6a716fd85d37378ac1de9993https://doi.org/10.1530/joe-13-0010
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential Proteomics of Omental and Subcutaneous Adipose Tissue Reflects Their Unalike Biochemical and Metabolic Properties2009 · 99 citations
  2. 2Proteomic analysis of human omental adipose tissue in the polycystic ovary syndrome using two-dimensional difference gel electrophoresis and mass spectrometry2007 · 112 citations
  3. 3International Association of Diabetes and Pregnancy Study Groups Recommendations on the Diagnosis and Classification of Hyperglycemia in Pregnancy2010 · 5,506 citations
  4. 4Abdominal Visceral and Subcutaneous Adipose Tissue Compartments2007 · 2,900 citations
  5. 5Gestational Diabetes Mellitus: Clinical Predictors and Long-Term Risk of Developing Type 2 Diabetes2007 · 380 citations