A ‘turn-on’ iridium(III) complex probe for visualizing mitochondrial SO2 fluctuation in cancer cells and tumor models

Q: What type of study is this?

This is a Experimental Study study.

Siyu Chen; M. Chen; An-Li Liu; Gao-Nan Li; Fabiao Yu; Zhi‐Gang Niu

doi:10.1039/d5dt01854d

January 1, 2025Dalton Transactions

A ‘turn-on’ iridium(III) complex probe for visualizing mitochondrial SO2 fluctuation in cancer cells and tumor models

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Key Points

The probe enables real-time visualization of mitochondrial SO2 fluctuations in cancer cells, enhancing diagnostic capabilities.
Abnormal SO2 levels were noted to correlate with tumor presence, indicating potential as an early biomarker.
Utilizing iridium(III) complex in tumor models demonstrates significant visual detection of localized SO2 changes.
Findings propose that SO2 fluctuation could be a pivotal factor in cancer biology and diagnostics.

Implication

A novel probe visualizes SO2 levels in cancer cells and tumor models, suggesting its role as a biomarker.

Abstract

Mitochondrial sulfur dioxide (SO2) plays critical biological roles in physiological processes. Notably, abnormal endogenous SO2 levels serve as potential biomarkers for early diagnosis of tumors. Therefore, visual detection of SO2...

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68de68e583cbc991d0a20fec https://doi.org/10.1039/d5dt01854d

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A ‘turn-on’ iridium(III) complex probe for visualizing mitochondrial SO2 fluctuation in cancer cells and tumor models

Key Points

Implication

Abstract

Discussion

Cite This Study

A ‘turn-on’ iridium(III) complex probe for visualizing mitochondrial SO2 fluctuation in cancer cells and tumor models

Key Points

Implication

Abstract

Discussion

Cite This Study

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