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Comprehensive umbrella review of meta-analysis on genetic polymorphisms (SNPs) and their links to hypertension

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This umbrella review summarizes 21 SNPs in hypertension, emphasizing the role of genetic factors and credibility analysis.

Strong associations were found between specific SNPs and hypertension risk, particularly ACE, ApoE, and TNF-α.
A total of 392,314 participants across 21 meta-analyses were included, enhancing the reliability of the findings.
Using a Random Forest model, the study identified key predictive SNPs that hold promise for clinical applications.
The findings support the importance of genetic factors in hypertension management and the potential for personalized medicine.

Ahmed Naseer Kaftan (2025) studied this question.

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