Why the study?
Do specific gene polymorphisms affect blood pressure progression and incident hypertension in white women free of hypertension at baseline?
Population
18,738 white women from a prospective cohort study who were free of hypertension at baseline
Comparison
77 previously characterized gene variants in 52… vs Different genotypes (reference alleles)
Design
Cohort
Follow-up
48 months for blood pressure progression; median 9.8 years…
Authors
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NPPA rs5063 modestly associated with BP progression; leaves open whether polymorphisms predict incident hypertension in normotensive women.
Do specific gene polymorphisms affect blood pressure progression and incident hypertension in white women free of hypertension at baseline?
NPPA gene polymorphisms may play a role in blood pressure progression, though genetic associations with incident hypertension were not significant after adjustment for multiple testing.
Conen et al. (2009) studied this question.
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