Natriuretic Peptide Precursor A Gene Polymorphisms and Risk of Blood Pressure Progression and Incident Hypertension
Why the study?
Do natriuretic peptide precursor A gene polymorphisms reduce the risk of blood pressure progression and incident hypertension in healthy, middle-aged women?
Population
18,437 healthy, middle-aged white women participating in the Women's Health Study who were free of…
Comparison
Presence of natriuretic peptide precursor A gene… vs Absence of these variants
Design
Cohort
Follow-up
9.8 years
Authors
Discussion
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Member takes
Implication
Supports NPPA variant research for hypertension prevention; does not yet change clinical risk assessment in women.
Structured PICO
Do natriuretic peptide precursor A gene polymorphisms reduce the risk of blood pressure progression and incident hypertension in healthy, middle-aged women?
P
Population
18,437 healthy, middle-aged white women participating in the Women's Health Study who were free of hypertension at baseline.
I
Intervention
Presence of natriuretic peptide precursor A gene polymorphisms (rs5063 G>A and rs5065 T>C) and inferred haplotypes
C
Comparator
Absence of these variants (referent genotypes/haplotypes, e.g., G-T haplotype)
O
Outcome
Blood pressure progression at 48 months and incident hypertension during the entire follow-uphard clinical
Polymorphisms in the natriuretic peptide precursor A gene (specifically rs5063) are associated with a lower risk of blood pressure progression and incident hypertension in healthy white women.
Cite This Study
Conen et al. (2007) studied this question.