March 1, 2000Clinical Science

Genetic analysis of the atrial natriuretic peptide gene in essential hypertension

Q: What are the key findings of this study?

The ANP gene polymorphism C-664G in the 5′-untranslated region was marginally associated with essential hypertension in a Japanese population (P=0.026).

Q: What is the clinical evidence from this study?

Study design: Case-Control. Population: Essential hypertension (n=582). Intervention: ANP gene polymorphisms (including C-664G) vs. Normotensive individuals. Primary outcome: Association with hypertension status (p=0.026).

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Key result

ANP gene C-664G polymorphism is marginally linked to essential hypertension in a Japanese population.

P=0.026
n=582

Why the study?

Do polymorphisms in the atrial natriuretic peptide (ANP) gene associate with essential hypertension or plasma ANP levels in a Japanese population?

Population

255 hypertensive and 225 normotensive Japanese individuals for a case-control study, and 102 healthy…

Comparison

Screening of a 3368-bp genomic fragment of the… vs Normotensive controls

Design

Case-control

Authors

NKNorihiro KATOKyoto University TSTakao SUGIYAMAThe Institute of Medical Science, Asahi Life Foundation HMHiroyuki MoritaUniversity of Toyama

Discussion

Member takes

Implication

No change to hypertension evaluation or treatment; leaves open a modest role for ANP variants in essential hypertension.

Study Design

Type

Case-Control (n=582)

Structured PICO

Do polymorphisms in the atrial natriuretic peptide (ANP) gene associate with essential hypertension or plasma ANP levels in a Japanese population?

Population

582 individuals, including 255 hypertensive and 225 normotensive Japanese subjects, and 102 healthy normotensive subjects, evaluated for associations between ANP gene polymorphisms and hypertension.

Exposure

Screening of a 3368-bp genomic fragment of the atrial natriuretic peptide (ANP) gene for polymorphisms

Comparator

Normotensive controls

Outcome

Association of ANP gene polymorphisms with hypertension status and plasma ANP levelssurrogate

Main Result

p-value: p=0.026

The C-664G polymorphism in the ANP gene may be weakly associated with essential hypertension in Japanese individuals, though low allele frequencies limit statistical power.

Limitations

Low allele frequency (<10%) of uncommon variants may have hampered detection of significant associations
Findings need to be examined in different ethnic groups
Low allele frequency (<10%) of uncommon variants in the Japanese population may have hampered detection of significant associations
Needs examination in different ethnic groups

Cite This Study

KATO et al. (2000) conducted a case-control in Essential hypertension (n=582). ANP gene polymorphisms (including C-664G) vs. Normotensive individuals was evaluated on Association with hypertension status (p=0.026). The ANP gene polymorphism C-664G in the 5′-untranslated region was marginally associated with essential hypertension in a Japanese population (P=0.026).

synapsesocial.com/papers/6aa20e56520b2d18c7ef9ede https://doi.org/10.1042/cs19990220

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March 1, 2000Clinical Science

Genetic analysis of the atrial natriuretic peptide gene in essential hypertension

View Full Paper

Ask AI

Bookmark

Key result

ANP gene C-664G polymorphism is marginally linked to essential hypertension in a Japanese population.

P=0.026
n=582

Why the study?

Do polymorphisms in the atrial natriuretic peptide (ANP) gene associate with essential hypertension or plasma ANP levels in a Japanese population?

Population

255 hypertensive and 225 normotensive Japanese individuals for a case-control study, and 102 healthy…

Comparison

Screening of a 3368-bp genomic fragment of the… vs Normotensive controls

Design

Case-control

Authors

NKNorihiro KATOKyoto University TSTakao SUGIYAMAThe Institute of Medical Science, Asahi Life Foundation HMHiroyuki MoritaUniversity of Toyama

Discussion

Member takes

Implication

No change to hypertension evaluation or treatment; leaves open a modest role for ANP variants in essential hypertension.

Study Design

Type

Case-Control (n=582)

Structured PICO

Do polymorphisms in the atrial natriuretic peptide (ANP) gene associate with essential hypertension or plasma ANP levels in a Japanese population?

Population

582 individuals, including 255 hypertensive and 225 normotensive Japanese subjects, and 102 healthy normotensive subjects, evaluated for associations between ANP gene polymorphisms and hypertension.

Exposure

Screening of a 3368-bp genomic fragment of the atrial natriuretic peptide (ANP) gene for polymorphisms

Comparator

Normotensive controls

Outcome

Association of ANP gene polymorphisms with hypertension status and plasma ANP levelssurrogate

Main Result

p-value: p=0.026

The C-664G polymorphism in the ANP gene may be weakly associated with essential hypertension in Japanese individuals, though low allele frequencies limit statistical power.

Limitations

Low allele frequency (<10%) of uncommon variants may have hampered detection of significant associations
Findings need to be examined in different ethnic groups
Low allele frequency (<10%) of uncommon variants in the Japanese population may have hampered detection of significant associations
Needs examination in different ethnic groups

Cite This Study

synapsesocial.com/papers/6aa20e56520b2d18c7ef9ede https://doi.org/10.1042/cs19990220

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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