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January 1, 2001Hypertension Research

Association Study between the Variants of the Human ANP Gene and Essential Hypertension.

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Why the study?

Are the G1837A and T2238C polymorphisms of the ANP gene associated with essential hypertension in a Japanese population?

Population

446 Japanese individuals, comprising 233 with essential hypertension and 213 age-matched normotensive…

Comparison

ANP gene markers G1837A and T2238C vs Normotensive controls

Design

Case-control

Authors

DRDolkun RahmutulaNihon UniversityTNTomohiro NakayamaNihon UniversityMSMasayoshi SomaNihon University

Discussion

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Implication

No support for ANP variant screening in Japanese essential hypertension; leaves open genetic contributions in other populations.

Structured PICO

Are the G1837A and T2238C polymorphisms of the ANP gene associated with essential hypertension in a Japanese population?

P
Population
446 Japanese individuals, comprising 233 with essential hypertension and 213 age-matched normotensive controls.
I
Intervention
ANP gene markers G1837A and T2238C
C
Comparator
Normotensive controls
O
Outcome
Association with essential hypertensionsurrogate

The G1837A and T2238C polymorphisms of the ANP gene are not associated with essential hypertension in the Japanese population.

Cite This Study

Rahmutula et al. (2001) studied this question.

synapsesocial.com/papers/6a6f92c784cc45bb7bdfa3aahttps://doi.org/10.1291/hypres.24.291

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Polymorphisms within the atrial natriuretic peptide gene in essential hypertension1995 · 77 citations
  2. 2Dysregulation of Atrial Natriuretic Factor in Hypertension-Prone Man*1990 · 43 citations
  3. 3An Insertion/Deletion Polymorphism in Intron 18 of the Type B Human Natriuretic Peptide Receptor Gene Is Not Associated with Cerebral Infarction.2000 · 15 citations
  4. 4Resting and volume-stimulated circulating atrial natriuretic peptide in young normotensive men with positive family histories of hypertension1991 · 20 citations
  5. 5Regulation of cardiac contractile proteins. Correlations between physiology and biochemistry.1984 · 127 citations