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October 2, 2025Open Access

Supplementary Figure S6 from Polyamine Depletion by D,L-α-Difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis

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Experimental analysis shows that DFMO treatment reduces polyamine levels in tumors, suggesting a role in ferroptosis induction.

DFMO treatment significantly reduced polyamine concentrations in tumors, leading to inhibited metastasis.
Ornithine decarboxylase activity was lower in orthotopic tumors compared to subcutaneous, indicating DFMO's effect.
Polyamine levels, specifically putrescine and spermidine, were diminished in orthotopic tumors treated with DFMO.
Ferroptosis induction via DFMO represents a promising therapeutic avenue for targeting Ewing sarcoma.

Offenbacher et al. (2025) studied this question.

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