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This is a Quantitative Study study.

October 2, 2025Open Access

Supplementary Figure S9 from Polyamine Depletion by D,L-α-Difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis

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Experiments demonstrate that DFMO combats spheroid formation in Ewing sarcoma, suggesting ferroptosis plays a crucial role.

DFMO significantly decreases spheroid formation in Ewing sarcoma cells, indicating its potential anti-metastatic effect.
Cell lines MHH-ES1 and SK-ES1 showed decreased spheroid formation upon DFMO treatment, with p-values indicating strong statistical significance.
Inhibitors of ferroptosis increased spheroid formation in conjunction with DFMO, highlighting the involvement of ferroptosis in this effect.
Apoptosis inhibition did not rescue spheroid formation, suggesting ferroptosis as a key pathway in overcoming DFMO's effects.

Offenbacher et al. (2025) studied this question.

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