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This is a Quantitative Study study.

October 2, 2025Open Access

Supplementary Figure S8 from Polyamine Depletion by D,L-α-Difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis

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DFMO treatment significantly increases lipid peroxidation in Ewing sarcoma cells, inhibiting metastasis.
Flow cytometry analysis revealed 25.1% MHH-ES1 and 41.4% SK-ES1 cells exhibited increased green fluorescence after DFMO treatment.
Analysis of lipid peroxidation was conducted using BODIPY581/591 fluorophore in ultra-low attachment plates.
Results indicate that polyamine depletion may enhance ferroptosis as a therapeutic strategy against Ewing sarcoma.

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DFMO treatment increases lipid peroxidation in Ewing sarcoma cells, suggesting a link to ferroptosis.

Offenbacher et al. (2025) studied this question.

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