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This is a Experimental Study study.

October 2, 2025Open Access

Supplementary Figure S7 from Polyamine Depletion by D,L-α-Difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis

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DFMO treatment does not activate caspase 3 in Ewing sarcoma cells, indicating a potential for inducing ferroptosis.
Caspase activity was substantially activated by etoposide in all tested cell lines, whereas DFMO showed no significant difference.
Live-cell analysis revealed no significant caspase activation with DFMO treatment across various concentrations, supporting the findings.
These insights suggest that DFMO may inhibit metastasis through ferroptosis without affecting apoptosis pathways.

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Supplementary analysis shows DFMO does not activate caspase in Ewing sarcoma cells, highlighting its potential effects on metastasis.

Offenbacher et al. (2025) studied this question.

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