Figure S4 from Development of Multivalent FAP-Targeted Small Molecule–Drug Conjugates with Tailored MMAE Release Kinetics

Matilde Bocci; Lucrezia Principi; Dario Neri; Samuele Cazzamalli; Ettore Gilardoni; Andrea Galbiati

doi:10.1158/1535-7163.30255506

October 1, 2025

Figure S4 from Development of Multivalent FAP-Targeted Small Molecule–Drug Conjugates with Tailored MMAE Release Kinetics

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Key Points

Treatment significantly affected tumor growth in mice, demonstrating the potential effectiveness of FAP-targeted strategies.
Daily measurements of tumor volumes indicated varying responses to OncoFAP-GlyPro-MMAE and TriOncoFAP-GlyPro-MMAE treatments.
Injections were administered intravenously, with doses ranging from 50 to 250 nmol/kg for each treatment type.
Tailored release kinetics of the conjugates could optimize efficacy in delivering therapeutic agents directly to tumors.

Implication

Observational analysis assesses tumor growth variations in mice treated with fap-targeted drug conjugates, suggesting tailored release kinetics may enhance treatment efficacy.

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Cite This Study

Bocci et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2196a https://doi.org/10.1158/1535-7163.30255506

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Figure S4 from Development of Multivalent FAP-Targeted Small Molecule–Drug Conjugates with Tailored MMAE Release Kinetics

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S4 from Development of Multivalent FAP-Targeted Small Molecule–Drug Conjugates with Tailored MMAE Release Kinetics

Key Points

Implication

Abstract

Discussion

Cite This Study

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