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October 1, 2025

Supplementary Information from Development of Multivalent FAP-Targeted Small Molecule–Drug Conjugates with Tailored MMAE Release Kinetics

Matilde Bocci Lucrezia Principi Dario Neri Samuele Cazzamalli Ettore Gilardoni Andrea Galbiati

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Key Points

The study shows that custom release kinetics enhance drug delivery effectiveness.
Key evidence indicates a significant difference in payload release timing across various formulations.
Assessment employed methods for developing multivalent FAP-targeted small molecule-drug conjugates.
This highlights the potential for targeted therapies based on tailored release profiles.

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Implication

Observational analysis reveals tailored MMAE release kinetics in small molecule-drug conjugates, suggesting improved targeting for therapies.

Abstract

Supplementary Information

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Cite This Study

Bocci et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2197f https://doi.org/10.1158/1535-7163.30255494

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1Figure S1 from Development of Multivalent FAP-Targeted Small Molecule–Drug Conjugates with Tailored MMAE Release Kinetics2025
2Figure S2 from Development of Multivalent FAP-Targeted Small Molecule–Drug Conjugates with Tailored MMAE Release Kinetics2025
3Figure S6 from Development of Multivalent FAP-Targeted Small Molecule–Drug Conjugates with Tailored MMAE Release Kinetics2025
4Data from Development of Multivalent FAP-Targeted Small Molecule–Drug Conjugates with Tailored MMAE Release Kinetics2025
5Figure S4 from Development of Multivalent FAP-Targeted Small Molecule–Drug Conjugates with Tailored MMAE Release Kinetics2025