October 2, 2025Open Access

Figure S2 from TIGIT Affects CAR NK-cell Effector Function in the Solid Tumor Microenvironment by Modulating Immune Synapse Strength

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TIGIT impacts the effector function of NK-cells within solid tumors, which is critical for immune response effectiveness.
Characterization revealed that tigit ligands are present in both PBMCs and tumor cell lines, influencing NK-cell interactions.
Analysis included examinations of immune synapse strength, determining its role in NK-cell functionality against tumors.
Understanding this relationship highlights potential therapeutic targets for enhancing NK-cell activity in cancer treatment.

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Characterization of tigit ligands in pbmc and tumor cell lines reveals immune synapse effects.

Characterization of TIGIT ligands in PBMCs and tumor cell lines.

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Navin et al. (2025) studied this question.

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Characterization of tigit ligands in pbmc and tumor cell lines reveals immune synapse effects.

Characterization of TIGIT ligands in PBMCs and tumor cell lines.