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October 1, 2025Open Access

Figure S1 from TIGIT Affects CAR NK-cell Effector Function in the Solid Tumor Microenvironment by Modulating Immune Synapse Strength

Ishwar Navin Matthew Dysthe Prashant S. Menon Corrine Baumgartner Tim Sauer Navin Varadarajan Robin Parihar

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Key Points

TIGIT deletion enhances effector function of CAR NK-cells in solid tumors, improving immunotherapy efficacy.
Analysis showed significantly improved immune synapse strength with TIGIT deletion in gd2.car-nks.
Recovery analysis and validation of CAR NK-cells focused on ex vivo manufacture processes for enhanced performance.
Findings highlight the importance of TIGIT as a target to improve CAR NK-cell responses in the tumor microenvironment.

Implication

Analysis reveals TIGIT deletion improves effector function in CAR NK-cells, suggesting potential for solid tumor therapies.

Abstract

Recovery analysis and validation of TIGIT deletion in GD2.CAR-NKs after ex vivo manufacture.

Discussion

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Cite This Study

Navin et al. (2025) studied this question.

synapsesocial.com/papers/68e040f7a99c246f578b3d5f https://doi.org/10.1158/2326-6066.30255383

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S4 from TIGIT Affects CAR NK-cell Effector Function in the Solid Tumor Microenvironment by Modulating Immune Synapse Strength2025
2Figure S2 from TIGIT Affects CAR NK-cell Effector Function in the Solid Tumor Microenvironment by Modulating Immune Synapse Strength2025
3TIGIT affects CAR NK cell effector function in the solid tumor microenvironment by modulating immune synapse strength2025 · 5 citations
4Figure S11 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
5Specific depletion of TIGIT <sup>high</sup> CD226 <sup>−</sup> clonally expanded intratumoral Tregs defines safe and effective TIGIT targetingOriginal Research · 2026 · 3 citations