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This is a Experimental Study study.

October 2, 2025Open Access

Figure S4 from TIGIT Affects CAR NK-cell Effector Function in the Solid Tumor Microenvironment by Modulating Immune Synapse Strength

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TIGIT deletion enhances the anti-tumor function of GD2.CAR-NK cells within solid tumors, indicating promising therapeutic potential.
The study found that immune synapse strength is modulated by TIGIT, impacting the effectiveness of CAR NK cells against tumors.
Characterization of CAR NK-cell responses to TIGIT deletion provides insights for improving cancer immunotherapies.
Understanding the mechanisms of immune synapse modulation could lead to better strategies for enhancing anti-tumor activity.

Analysis reveals TIGIT deletion improves anti-tumor activity in GD2.CAR-NK cells, suggesting immune synapse modulation effects.

Characterizing the role of TIGIT deletion in enhancing GD2.CAR-NK anti-tumor activity.

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Navin et al. (2025) studied this question.

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Analysis reveals TIGIT deletion improves anti-tumor activity in GD2.CAR-NK cells, suggesting immune synapse modulation effects.

Characterizing the role of TIGIT deletion in enhancing GD2.CAR-NK anti-tumor activity.