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August 1, 2025

Figure S11 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8⁺ T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells

Mélanie Desbois Thierry Giffon Poonam Yakkundi Carolyn R. Denson Keerthana Sekar Kevin C. Hart Daniel Santos Susan E. Calhoun Kathryn Logronio Sivani Pandey Dean Ng Avneesh K. Saini Beatrice T. Wang Bruce A. Keyt Angus M. Sinclair Maya F. Kotturi

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Key Points

MAIN FINDING: IGM-7354 induces significant NK and CD8 T cell-mediated cytotoxicity against PD-L1-positive tumors.
KEY EVIDENCE: The immunocytokine improves CAR-T cell responses in a dose-dependent manner during treatment.
APPROACH: The study evaluates the activation of immune cells by IGM-7354 in laboratory models.
SIGNIFICANCE: Enhancing the immune response against tumors could lead to improved cancer therapies using IGM-7354.

Implication

Supplemental figure shows IGM-7354 enhances NK and CD8 T cell activation in tumor treatment, suggesting it may improve anti-tumor immunity.

Abstract

Supplemental Figure 11. IGM-7354 enhances the CAR-T anti-tumor responses in a dose-dependent manner.

Discussion

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Cite This Study

Desbois et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d01ff https://doi.org/10.1158/2326-6066.29760505

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S3 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
2Figure S9 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
3Figure S6 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
4Figure S7 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
5Figure S2 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025