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August 1, 2025

Figure S10 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8⁺ T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells

Mélanie Desbois Thierry Giffon Poonam Yakkundi Carolyn R. Denson Keerthana Sekar Kevin C. Hart Daniel Santos Susan E. Calhoun Kathryn Logronio Sivani Pandey Dean Ng Avneesh K. Saini Beatrice T. Wang Bruce A. Keyt Angus M. Sinclair Maya F. Kotturi

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Key Points

IGM-7354 significantly boosts NK and CD8+ T cell proliferation against PD-L1-positive tumor cells.
The immune response mechanism involves heightened cytotoxicity mediated by IGM-7354.
Effective interaction between immunocytokine IGM-7354 and immune cells was observed in mouse models.
Findings suggest IGM-7354's role in enhancing cancer immunotherapy approaches targeting PD-L1.

Implication

Supplemental figure reveals IGM-7354 induces enhanced NK and CD8+ T cell activity, indicating potential for cancer therapy.

Abstract

Supplemental Figure 10. Proliferation of mouse NK and CD8+ T cells were observed in presence of IGM7354.

Discussion

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Cite This Study

Desbois et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0246 https://doi.org/10.1158/2326-6066.29760508

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S9 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
2Figure S3 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
3Figure S7 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
4Figure S6 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
5Figure S2 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025