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August 1, 2025

Figure S7 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8⁺ T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells

Mélanie Desbois Thierry Giffon Poonam Yakkundi Carolyn R. Denson Keerthana Sekar Kevin C. Hart Daniel Santos Susan E. Calhoun Kathryn Logronio Sivani Pandey Dean Ng Avneesh K. Saini Beatrice T. Wang Bruce A. Keyt Angus M. Sinclair Maya F. Kotturi

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Key Points

MAIN FINDING: IGM-7354 significantly enhances cytotoxicity against PD-L1-positive MDA-MB-231 tumor cells.
KEY EVIDENCE: The immunocytokine promotes the activation of NK and CD8+ T cells to effectively kill tumor cells.
APPROACH: The research involved in vitro assays to measure the impact of IGM-7354 on immune cell functionality.
SIGNIFICANCE: This work highlights a new potential therapeutic strategy for targeting cancer cells using immune modulation.

Implication

In vitro analysis reveals IGM-7354 boosts cytotoxic activity of nk cells and cd8 t cells against tumor cells, indicating potential cancer therapy.

Abstract

Supplemental Figure 7. IGM-7354 promotes the killing of MDA-MB-231 tumor cells in vitro and preferentially modulates CD8+ T cells.

Discussion

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Cite This Study

Desbois et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d01d0 https://doi.org/10.1158/2326-6066.29760481

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S6 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
2Figure S3 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
3Figure S9 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
4Figure S10 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
5Figure S2 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025