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August 1, 2025

Figure S3 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8⁺ T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells

Mélanie Desbois Thierry Giffon Poonam Yakkundi Carolyn R. Denson Keerthana Sekar Kevin C. Hart Daniel Santos Susan E. Calhoun Kathryn Logronio Sivani Pandey Dean Ng Avneesh K. Saini Beatrice T. Wang Bruce A. Keyt Angus M. Sinclair Maya F. Kotturi

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Key Points

IGM-7354 promotes the expansion of nk cells and cd8+ t cells in vitro.
Cytotoxicity is directed towards pd-l1 positive tumor cells, enhancing immune response.
The method involves testing the immunocytokine's effects on immune cell populations.
These findings indicate potential therapeutic applications for targeting tumor cells in cancer treatment.

Implication

Supplemental data shows IGM-7354 enhances NK and CD8+ T cell cytotoxicity in PD-L1 positive tumors, suggesting potential for cancer therapy.

Abstract

Supplemental Figure 3. IGM-7354 preferentially expands NK and CD8+ T cells in vitro.

Discussion

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Cite This Study

Desbois et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d01d2 https://doi.org/10.1158/2326-6066.29760496

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S9 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
2Figure S7 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
3Figure S6 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
4Figure S10 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
5Figure S2 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025