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August 1, 2025

Figure S6 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8⁺ T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells

Mélanie Desbois Thierry Giffon Poonam Yakkundi Carolyn R. Denson Keerthana Sekar Kevin C. Hart Daniel Santos Susan E. Calhoun Kathryn Logronio Sivani Pandey Dean Ng Avneesh K. Saini Beatrice T. Wang Bruce A. Keyt Angus M. Sinclair Maya F. Kotturi

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Key Points

IGM-7354 induces cytotoxicity in PD-L1-positive tumor cells by enhancing NK and CD8+ T cell activity.
In vitro experiments reveal IGM-7354 effectively targets MDA-MB-231 tumor cells, showing strong therapeutic potential.
The study illustrates how IL15 fusion in IGM-7354 modulates immune cell functions to combat cancer.
Findings suggest that enhancing immune response against tumors could improve cancer treatment outcomes.

Implication

Supplemental figure shows IGM-7354 enhances cytotoxicity of NK and CD8+ T cells against tumor cells, implying potential in cancer immunotherapy.

Abstract

Supplemental Figure 6. IGM-7354 promotes the killing of MDA-MB-231 tumor cells in vitro and preferentially modulates CD8+ T cells.

Discussion

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Cite This Study

Desbois et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0257 https://doi.org/10.1158/2326-6066.29760484

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S7 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
2Figure S3 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
3Figure S9 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
4Figure S2 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025
5Figure S10 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8<sup>+</sup> T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells2025