Figure S2 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8⁺ T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells

Mélanie Desbois; Thierry Giffon; Poonam Yakkundi; Carolyn R. Denson; Keerthana Sekar; Kevin C. Hart; Daniel Santos; Susan E. Calhoun; Kathryn Logronio; Sivani Pandey; Dean Ng; Avneesh K. Saini; Beatrice T. Wang; Bruce A. Keyt; Angus M. Sinclair; Maya F. Kotturi

doi:10.1158/2326-6066.29760499

August 1, 2025

Figure S2 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8⁺ T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells

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Key Points

IGM-7354 enhances cytotoxicity against PD-L1 positive tumor cells through NK and CD8+ T cell activation.
Observations indicate significant binding properties of IGM-7354 related to PD-L1 and IL15.
The approach involved examining the immunocytokine's effects in vitro on certain immune cells and tumor cells.
Understanding IGM-7354's mechanism could lead to improved cancer therapies targeting PD-L1.

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Implication

Supplementary figure shows IGM-7354 improves cytotoxicity in PD-L1 positive tumor cells by activating nk and cd8+ t cells, suggesting a novel therapeutic approach.

Abstract

Supplementary Figure 2. Binding properties of IGM-7354.

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Cite This Study

Desbois et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d01d3 https://doi.org/10.1158/2326-6066.29760499

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Figure S2 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8⁺ T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Figure S2 from IGM-7354, an Immunocytokine with IL15 Fused to an Anti–PD-L1 IgM, Induces NK and CD8⁺ T cell–Mediated Cytotoxicity of PD-L1–Positive Tumor Cells

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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