Supplementary Figure 7 from Oxytocin Receptor Regulates the Hippo/YAP Axis to Drive Hepatocarcinogenesis

Huijie Yang; Jin Cui; Peng Su; Xiujie Cui; Haojie Guo; Penghe Yang; Shuqing Zhang; Chenmiao Zhang; Mingxi Fu; Zhongbo Li; Yinlu Ding; Ting Zhuang; Jian Zhu; Xiaodong Tan

doi:10.1158/0008-5472.30255553

October 1, 2025

Supplementary Figure 7 from Oxytocin Receptor Regulates the Hippo/YAP Axis to Drive Hepatocarcinogenesis

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Key Points

Hepatocellular carcinoma progression is driven by oxytocin receptor activation of the hippo/yap axis, enhancing tumor growth.
The oxytocin receptor's role in hepatocellular carcinoma was evidenced by observed alterations in the hippo/yap signaling pathway.
Mechanistic insights reveal that targeting the oxytocin receptor might provide new therapeutic strategies against hepatocellular carcinoma.
The findings support further investigation into the hippo/yap axis's involvement in cancer biology and potential treatment options.

Implication

Activation of the hippo/yap axis drives hepatocellular carcinoma progression through the oxytocin receptor, suggesting a potential target for interventions.

Abstract

The OXTR facilitates hepatocellular carcinoma progression via activation of the Hippo/YAP axis

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Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a82 https://doi.org/10.1158/0008-5472.30255553

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Supplementary Figure 7 from Oxytocin Receptor Regulates the Hippo/YAP Axis to Drive Hepatocarcinogenesis

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 7 from Oxytocin Receptor Regulates the Hippo/YAP Axis to Drive Hepatocarcinogenesis

Key Points

Implication

Abstract

Discussion

Cite This Study

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