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October 2, 2025Deleted JournalOpen Access

Intraoperative and Postoperative Nefopam Administration for Video-assisted Thoracoscopic Lobectomy Pain: A Multicenter, Randomized, Controlled Trial

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Nefopam infusion did not significantly reduce morphine consumption post-surgery, indicating limited effectiveness in pain management.
Key metrics showed no significant differences in postoperative morphine amounts or NRS pain scores at all measured times post-surgery.
This study utilized a double-blind, randomized, controlled trial design to compare nefopam with normal saline in patients undergoing VATS lobectomy.
Findings highlight the need for further investigation into effective pain management strategies in thoracoscopic surgery.

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Multicenter trial assesses nefopam's effects on pain and opioid use in VATS lobectomy, suggesting limited impact.

Khamtuikrua et al. (2025) studied this question.

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