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June 28, 2026Scientific ReportsOpen Access

Adding nefopam to oxycodone-based patient-controlled analgesia provides noninferior analgesia with opioid sparing after laparoscopic surgery

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Authors

JOJuyeon OhELEun‐Ju LeeKKKyung Mi Kim

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Overview

Randomized trial evaluates analgesic efficacy of nefopam with oxycodone in surgery, implying opioid reduction.

Key Points

  • This trial aims to assess the efficacy and opioid-sparing effect of nefopam combined with oxycodone after laparoscopic surgery.
  • Single-center, randomized, single-blind, non-inferiority trial
  • 246 patients assigned to three groups with different treatment protocols
  • Primary endpoint was VAS pain score at 24 hours postoperatively.
  • Both nefopam-oxycodone combinations provided non-inferior analgesia compared to oxycodone monotherapy (mean difference, Group A vs. C: -0.33; Group B vs. C: 0.00).
  • Cumulative oxycodone consumption was reduced by 26.2% in Group A and 46.7% in Group B compared to control (both P < 0.001).
  • No significant differences in adverse events, sedation, or respiratory depression among groups.

Cite This Study

Oh et al. (2026) studied this question.

synapsesocial.com/papers/6a40b96161bb0a67205c5990https://doi.org/10.1038/s41598-026-59710-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Efficacy of Low Dose Nefopam Combined with Fentanyl Injection for Controlling Immediate Postoperative Pain After Laparoscopic Surgery. A Double-blinded, Randomized Controlled Trial2024
  2. 2Comparison of Nefopam-Based Patient-Controlled Analgesia with Opioid-Based Patient-Controlled Analgesia for Postoperative Pain Management in Immediate Breast Reconstruction Surgery: A Randomized Controlled Trial2024
  3. 3Combined nefopam-fentanyl use in PCA for postoperative analgesia in spinal surgery patients: a randomized, controlled, single-blind trial2024 · 1 citations
  4. 4SRS42 - The safety and efficacy of perioperative nefopam for analgesia in spine surgery: a systematic review and meta-analysis of randomised controlled trials2026
  5. 5Impact of Intraoperative Nefopam on Postoperative Pain, Opioid Use, and Recovery Quality with Parietal Pain Block in Single-Port Robotic Cholecystectomy: A Prospective Randomized Controlled Trial2024 · 3 citations