What question did this study set out to answer?

This review aims to assess the safety and efficacy of nefopam as an analgesic in perioperative spine surgery.

SRS42 - The safety and efficacy of perioperative nefopam for analgesia in spine surgery: a systematic review and meta-analysis of randomised controlled trials

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Systematic review evaluates nefopam's analgesic effects in spine surgery, suggesting potential opioid reduction while lacking impact on pain scores.

This review aims to assess the safety and efficacy of nefopam as an analgesic in perioperative spine surgery.
Conducted a systematic review and meta-analysis of randomised controlled trials.
Searched databases including Medline, Embase, Scopus, and Cochrane up to May 2025.
Analyzed opioid consumption, pain scores, adverse effects, and hospital stay using RevMan software.
Nefopam reduced 24-hour opioid use when combined with fentanyl, but not with morphine.
No significant effect on acute incisional or neuropathic pain scores was observed.
Nefopam had no impact on the length of hospital stay or adverse effects.

Okechukwu et al. (2026) studied this question.

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Systematic review evaluates nefopam's analgesic effects in spine surgery, suggesting potential opioid reduction while lacking impact on pain scores.