A randomized trial finds that nefopam reduces opioid needs after spinal fusion, suggesting a new pain management strategy.
In patients undergoing multilevel degenerative lumbar spinal fusion, continuous intravenous nefopam infusion significantly reduced postoperative opioid requirements without worsening adverse events. Nefopam may be a useful opioid-sparing adjunct in multimodal postoperative pain protocols for major spine surgery.
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Santipas et al. (2026) studied this question.
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