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October 3, 2025Critical CareOpen Access

The effects of vasopressor choice on renal outcomes in septic shock: a systematic review of randomised trials as a guide for future research

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Authors

RMRory McDonaldMBMichael BurnsAWAdrian Wong

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Overview

Systematic review assesses renal effects of vasopressors in septic shock patients, suggesting limited evidence.

Key Points

  • No significant effect on AKI incidence based on vasopressor choice was identified.
  • Among the 4259 patients across 17 studies, only one study revealed a significant benefit of vasopressin.
  • The study highlights the need for standardized renal outcome reporting in future trials.
  • Heterogeneity in populations and study designs limited the ability to draw firm conclusions.

Cite This Study

McDonald et al. (2025) studied this question.

synapsesocial.com/papers/68e02f34f0e39f13e7fa20edhttps://doi.org/10.1186/s13054-025-05573-7
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Also Consider

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  1. 1A PILOT STUDY OF ANGIOTENSIN II AS PRIMARY VASOPRESSOR IN CRITICALLY ILL ADULTS WITH VASODILATORY HYPOTENSION: THE ARAMIS STUDY2023 · 54 citations
  2. 2Recommendations for clinical trial design in acute kidney injury from the 31st acute disease quality initiative consensus conference. A consensus statement2024 · 9 citations
  3. 3Acute Renal Failure in Critically Ill Patients<SUBTITLE>A Multinational, Multicenter Study</SUBTITLE>2005 · 4,243 citations
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