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November 18, 2025Frontiers in PharmacologyOpen Access

Comparison of short-term and long-term renal function effects of vasopressin and norepinephrine in patients with septic shock: a systematic review and meta-analysis

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Authors

HWHongyu WangXLXilin LiuHZHong Zhang

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Overview

Systematic review shows vasopressin reduces serum creatinine and renal replacement therapy rates in septic shock patients, implying potential renal protective effects.

Key Points

  • To compare the renal function effects of vasopressin and norepinephrine in patients with septic shock.
  • Systematic search of databases for relevant studies
  • Comparison of renal function outcomes between vasopressin and norepinephrine
  • Inclusion of adult patients with septic shock
  • No significant differences in AKI incidence or urine output between treatments
  • Vasopressin linked to lower serum creatinine levels
  • Reduced renal replacement therapy utilization rate with vasopressin

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/6924fef4c0ce034ddc351c3ehttps://doi.org/10.3389/fphar.2025.1669636
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical efficacy and safety of vasopressin and its analogues in patients with septic shock: a meta-analysis and trial sequential analysis2024
  2. 2Norepinephrine Versus Vasopressin as First-Line Vasopressor Therapy in Septic Shock: Implications for Patients Presenting to the Emergency Department2026
  3. 3The effects of vasopressor choice on renal outcomes in septic shock: a systematic review of randomised trials as a guide for future research2025
  4. 4A Systematic Review and Meta-Analysis of the Timing of Vasopressor Therapy in Patients with Septic Shock: Assessing Clinical Outcomes and Implication2024
  5. 5Evidence Maps of Vasopressor Use in Adult Patients With Septic Shock: An Umbrella Review2026