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October 3, 2025CancersOpen Access

The Tumor Environment in Peritoneal Carcinomatosis and Malignant Pleural Effusions: Implications for Therapy

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Authors

PMPaige O. MirskyPWPatrick L. WagnerMMMaja Mandic-Popov

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Overview

Analysis reveals shared cytokines and T cell suppression in peritoneal carcinomatosis and malignant pleural effusions, indicating new therapeutic potential.

Key Points

  • The tumor environment in peritoneal carcinomatosis promotes aggressive cancer behavior while recruiting and suppressing T cells.
  • Current therapies for peritoneal carcinomatosis and malignant pleural effusions show bleak outcomes, pointing to a need for novel approaches.
  • Cytokines and secretomic components play a critical role in shaping the tumor microenvironment, facilitating treatment resistance.
  • Understanding the interactions within the tumor environment can enhance immunotherapeutic strategies for these severe conditions.

Cite This Study

Mirsky et al. (2025) studied this question.

synapsesocial.com/papers/68e02f3cf0e39f13e7fa2653https://doi.org/10.3390/cancers17193217
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Malignant Pleural Effusion and Tumor Immunity2024
  2. 2Peritoneal Carcinoma Unveiling a Hidden Threat: A Case of Malignant Pericardial Effusion2023 · 2 citations
  3. 3C78-18 When Cytology Isn’t Enough: Diagnostic Challenges in Pleomorphic Carcinoma With Malignant Pleural Effusion2026
  4. 4Changes in the immune tumor microenvironment of peritoneal mesothelioma under intraperitoneal chemotherapy2025
  5. 5Unraveling the multidimensional pleural ecosystem of lung cancer-associated malignant pleural effusion2026