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October 3, 2025Open Access

Gene editing of Nicotiana benthamiana architecture for space-efficient production of recombinant proteins in controlled environments

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Authors

BGBenoit GirouxKLKristina LeBreuxLFLouis Feyzeau

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Overview

CRISPR-Cas9 gene editing enhances recombinant protein yields in compact Nicotiana benthamiana mutants, suggesting improved vertical farming potential.

Key Points

  • Gene editing led to a 45% to 50% reduction in plant size without sacrificing protein yields.
  • Strigolactone depletion altered growth patterns but maintained the overall growth rate of Nicotiana benthamiana.
  • The ΔCCD mutants exhibited significant changes in auxin/cytokinin ratios, benefiting vertical farming systems.
  • This approach shows promise for optimizing space in biopharmaceutical production settings.

Cite This Study

Giroux et al. (2025) studied this question.

synapsesocial.com/papers/68e02f40f0e39f13e7fa27dahttps://doi.org/10.1101/2025.10.01.679797
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gene Editing of <i>Nicotiana benthamiana</i> Architecture for Space‐Efficient Production of Recombinant Proteins in Closed Environments2026 · 2 citations
  2. 2Engineering Conditional Transgene Expression in Nicotiana benthamiana.2025 · 10 citations
  3. 3Optimizing Plant Biofactories: Enhancing Recombinant Protein Production in Nicotiana benthamiana through Phytoplasma Effectors2024 · 2 citations
  4. 4Overcoming N-glycosylation challenges through multiplex CRISPR/Cas9-mediated editing of seven glycosyltransferase homologs in Nicotiana benthamiana2024
  5. 5Multiplex CRISPR/Cas9-mediated editing of seven glycosyltransferase homologs in Nicotiana benthamiana to produce stable, Cas9-free, glycoengineered plants2025 · 2 citations