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This is a In Vitro Study study.

October 3, 2025

The Role of Tyrosinase in Hyperpigmentation Disorder: A Focus on In-Vitro and In-Silico Studies on Natural tyrosinase Inhibitors from Calotropis procera

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In vitro studies discovered natural tyrosinase inhibitors from Calotropis procera, highlighting potential in treating hyperpigmentation disorders.

BECpL achieved 88.02% tyrosinase inhibition at 500 μg/mL, a level comparable to Kojic acid's 88.45%.
IC50 values for BECpL, EECpL, and Kojic Acid were 70.54 μg/mL, 74.05 μg/mL, and 78.40 μg/mL, respectively.
Liquid chromatography-mass spectrometry identified 15 phytochemicals from BECpL, suggesting its diverse composition.
Bioactive phytochemicals showed significant potential for natural tyrosinase inhibitors, emphasizing further research on their safety.

Areh et al. (2025) studied this question.

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In vitro studies discovered natural tyrosinase inhibitors from Calotropis procera, highlighting potential in treating hyperpigmentation disorders.