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This is a Experimental Study study (also classified as: Quantitative Study).

October 3, 2025Open Access

Multivariate analysis of glycogenes reveals coordinated regulation of immunoglobulin glycosylation in an immortalized human B cell system

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In vitro analysis explores cytokine-driven regulation of immunoglobulin glycosylation in B lymphocytes, highlighting glycogene roles.

Cytokine exposure shapes both glycogene expression and IgG glycosylation profiles in human B cells.
Transcriptomic profiling identifies distinct glycogene signatures associated with varying cytokine conditions.
Machine learning models reliably distinguish stimulation effects through glycogene expression patterns.
Understanding these mechanisms could impact approaches to autoimmune diseases, infections, and vaccine responses.

Wiggins et al. (2025) studied this question.

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