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This research aims to explore how IL-10 affects IgG Fc glycosylation and its relation to immune responses during immunization.

July 15, 2026Biomarker ResearchOpen Access

Interleukin-10 enhances IgG galactosylation and sialylation

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Randomized trial investigates IL-10's impact on IgG glycosylation in mice, suggesting its potential in vaccination.

This research aims to explore how IL-10 affects IgG Fc glycosylation and its relation to immune responses during immunization.
Examined IL-10 receptor blockade effects on IgG Fc glycosylation post-immunization with a model protein and Alum
Used IL-10 reporter mice to identify double-producing T follicular cells
Conducted ex vivo B cell culture experiments to assess the interaction between IL-10 and IFNg.
Blockade of IL-10 receptor reduced IgG1 Fc galactosylation and sialylation with decreased St6gal1 expression (p<0.05).
Alum immunization increased both Fc galactosylation and sialylation alongside elevated frequencies of IFNg-producing CD4+ T cells (p<0.01).
IL-10 was shown to counteract IFNg's suppression of St6gal1 in B cells, promoting enhanced glycosylation.

Lunding et al. (2026) studied this question.

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