What question did this study set out to answer?

This study aims to uncover the mechanisms driving Fc glycosylation in IgG and its effects on antibody function.

B Cell Activation Pathways Dictate the Effector Profile of Secreted IgG through Differential Fc Glycosylation 2257228

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Experimental analysis shows that B cell activation pathways regulate IgG glycosylation, impacting inflammation levels.

This study aims to uncover the mechanisms driving Fc glycosylation in IgG and its effects on antibody function.
Stimulated IgG+ memory B cells from healthy donors to induce antibody-secreting cell differentiation.
Compared T-cell-dependent and innate Toll-like receptor-mediated activation pathways.
Analyzed IgG glycosylation using Whole Immunoglobulin Glycoprofiling with Asymmetric Monitoring mass spectrometry.
T-cell-dependent activation increased galactosylation and sialylation in IgG (p<0.05).
Mono-sialylated Fc exhibited a significant distribution difference between T-cell-dependent and TLR activation.
Findings suggest T-cell-independent responses create more pro-inflammatory IgG with reduced glycosylation.

Gunduz et al. (2026) studied this question.

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