Endothelial cells sialylate IgG within the FcRn-mediated recycling pathway

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Analysis reveals that endothelial cells regulate IgG sialylation during pregnancy and inflammation, suggesting impacts on immune response.

Down-regulation of IgG sialylation occurs with inflammatory signals, indicating a dynamic regulatory mechanism.
Key findings highlight the role of endothelial cells in modulating IgG function through sialic acid addition.
IgG sialylation and its regulation during pregnancy contribute to understanding inflammatory disease mechanisms.
Potential implications for how IgG glycosylation influences Fc-containing pharmaceuticals in clinical settings.

Long et al. (2025) studied this question.

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Analysis reveals that endothelial cells regulate IgG sialylation during pregnancy and inflammation, suggesting impacts on immune response.