IgG sialylation occurs in B cells pre antibody secretion

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Sialylation of the IgG Fc fragment occurs exclusively within B cells prior to antibody secretion, refuting models of extracellular sialylation.
Assessment of bone marrow chimeric mice with B cell-specific deletion of ST6Gal1 confirms that intracellular glycosylation precedes secretion.
ST6Gal1 expression confers a developmental advantage allowing plasma cells to dominate serum IgG pools; mouse model, further preclinical work needed.

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Chimeric mouse study demonstrates that IgG sialylation occurs exclusively inside B cells before secretion, highlighting intracellular mechanisms.

Werner et al. (2024) studied this question.

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Chimeric mouse study demonstrates that IgG sialylation occurs exclusively inside B cells before secretion, highlighting intracellular mechanisms.