Analysis compares classic and integrated algorithms for lupus anticoagulant testing, indicating that the integrated algorithm may detect more positive cases.
Key Points
The integrated algorithm identified significantly more positive lupus anticoagulant samples than the classic algorithm.
Among 410 LA-positive specimens, 112 were only detected using the integrated algorithm, accounting for 27.3%.
Many laboratories are trying to minimize laboratory developed tests due to pending FDA changes in the U.S.
Further investigation is needed to evaluate the clinical significance of the additional positive samples detected.