What type of study is this?

This is a Systematic Review study.

October 13, 2025The International Journal of Medical Science and Health ResearchOpen Access

Laboratory Diagnosis of Lupus Anticoagulants: A Systematic Review of Assay Performance, Pre-analytical Challenges, and Clinical Utility

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Authors

WPWahyu Agus Prastyo ANArtha Investari NugraheniSultan Agung Islamic University MAMutia Ruliana AyuningrumSultan Agung Islamic University

Discussion

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Implication

This systematic review evaluates assay performance and pre-analytical challenges in diagnosing lupus anticoagulants, highlighting implications for clinical utility.

Key Points

A dual-assay strategy using dRVVT and SCT yields the best diagnostic sensitivity and specificity for lupus anticoagulant detection.
Pre-analytical variables such as platelet contamination can significantly affect diagnostic accuracy, risking false-negative results.
Direct oral anticoagulants, especially rivaroxaban and apixaban, lead to high rates of false-positive results in lupus anticoagulant assays.
Persistent lupus anticoagulant positivity is strongly correlated with adverse pregnancy outcomes and thrombosis in high-risk patient populations.

Cite This Study

Prastyo et al. (2025) studied this question.

synapsesocial.com/papers/68ec51e642911f61ef8b251b https://doi.org/10.70070/q03b8c43

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October 13, 2025The International Journal of Medical Science and Health ResearchOpen Access

Laboratory Diagnosis of Lupus Anticoagulants: A Systematic Review of Assay Performance, Pre-analytical Challenges, and Clinical Utility

View Full Paper

Ask AI

Bookmark

Authors

WPWahyu Agus Prastyo ANArtha Investari NugraheniSultan Agung Islamic University MAMutia Ruliana AyuningrumSultan Agung Islamic University

Discussion

Member takes

Implication

This systematic review evaluates assay performance and pre-analytical challenges in diagnosing lupus anticoagulants, highlighting implications for clinical utility.

Key Points

A dual-assay strategy using dRVVT and SCT yields the best diagnostic sensitivity and specificity for lupus anticoagulant detection.
Pre-analytical variables such as platelet contamination can significantly affect diagnostic accuracy, risking false-negative results.
Direct oral anticoagulants, especially rivaroxaban and apixaban, lead to high rates of false-positive results in lupus anticoagulant assays.
Persistent lupus anticoagulant positivity is strongly correlated with adverse pregnancy outcomes and thrombosis in high-risk patient populations.

Cite This Study

Prastyo et al. (2025) studied this question.

synapsesocial.com/papers/68ec51e642911f61ef8b251b https://doi.org/10.70070/q03b8c43

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